It can be considered as an ecodisease, any disorder of structure or
function in humans, animals or plants, caused by intra or extracellular
accumulations of unrecycled cellular waste material (=micro-residues). Such
aggregations may have endogenous origins and causes, or they can be related to
environmental sources and factors; or both.
In Humans, normally and biologically seen, all known chronic diseases can be
viewed as ecodiseases. However, this proposed restriction has namely as goal to
draw attention to the forgotten biological phenomenon of untreated
micro-residues amassing in living organisms, its causes and its serious
In humans, the origins and causes of unrecycled micro-residues accumulations can be traced back to:
· Long-time human exposure to harmful environmental agents (Viruses, Bacteria, Radiations, Pesticides, Additives, Alcohol, Drugs, Tobacco, etc.) engenders, first and above all, a permanent damage to cells, to their components and to other cell tissues structures. The result of such persistent injuries is an incessant generation of micro-residues that must be removed, degraded and recycled.
· Unrecycled micro-residues can also have direct exogenous sources consisting of ingested, applied or inhaled molecules that the human body cannot use, excrete or recycle, shortly, because of the lack of competent enzymes.
Acquired or inherited genetic alterations are manifested, first, by a permanent
generation of aberrant and, most of time, inactive proteins which destination
cannot be other than the recycling procedure. Nevertheless, the extent of the
problem is when such altered protein forms a part of a functional complex
molecule or pathway. All units that form such structure may then remain until
and must be recycled. Secondly, ........
Gaining insight into the pathological processes:
The phenomenon of cell
degeneration, characteristic of various human diseases, arises on a
pathological background of unrecycled micro-residues accumulations. Such
deposits physically disrupt tissue architecture and activity. They also
perturbate the cytoskeletal network, the vesicular trafficking and cause damage
to vital cell organelles.
Such conditions, this
crowding effect occurs as well in cancers that are biologically also ranked
among the human degenerative diseases. Nonetheless, affected cells, depending
on their current replicative potential, can evade such chaos and subsequent
cell degeneration by triggering an irreversible functional transition for a
beneficial and specific purpose that consists in recycling all their
accumulated micro-residues before a subtle death. Except that such immune-like
cellular adventure usually faces the amyloidogenic transformation of
accumulated unrecycled micro-residues to insoluble, unrecyclable deposits......More
Examples of human ecodiseases:
- All Benign and Malignant tumors. - Amyloidosis .
- Diabetes mellitus type II. - Chronic traumatic encephalopathy.
- Parkinson’s disease. - Prion diseases.
- Alzheimer’s disease. - Cardiovascular diseases.
- Macular degeneration. - Multiple system atrophy.
- Amyotrophic lateral sclerosis. - Early Immunosenescence .
Atherosclerosis. - ......etc.