Ecodisease


It can be considered as an ecodisease, any disorder of structure or function in humans, animals or plants, caused by intra or extracellular accumulations of unrecycled micro-residues. Such aggregations may have endogenous origins and causes, or they can be related to environmental sources and factors; or both.
In Humans, normally and biologically seen, all known chronic diseases can be viewed as ecodiseases.  Whatever, this proposed restriction has namely as goal to draw attention to the forgotten biological phenomenon of untreated micro-residues amassing in living organisms,  its causes and its serious pathological consequences.


Unrecycled micro-residues: 

In humans, the origins and causes of unrecycled micro-residues accumulations can be traced back to:

·       Long-time human exposure to harmful environmental agents (Viruses, Bacteria, Radiations, Pesticides, Additives, Alcohol, Drugs, Tobacco, etc.) engenders, first and above all, a permanent damage to cells, to their components and to other cell tissues structures. The result of such persistent injuries is an incessant generation of micro-residues that must be removed, degraded and recycled. 

·         Acquired or inherited genetic alterations are manifested, first, by a permanent generation of aberrant and, most of time, inactive proteins which destination cannot be other than the recycling procedure. Nevertheless, the extent of the problem is when such altered protein forms a part of a functional complex molecule or pathway. All units that form such structure may then remain until and must be recycled. Secondly, ........  

·       Unrecycled micro-residues can also have direct exogenous sources consisting of ingested, applied or inhaled molecules that the human body cannot use, extract or recycle, shortly, because of the lack of competent enzymes. 

The phenomenon of cell degeneration, characteristic of various human diseases, arises on a pathological background of unrecycled micro-residues accumulations. Such deposits physically disrupt tissue architecture and activity. They also perturbate the cytoskeletal network, the vesicular trafficking and cause damage to vital cell organelles. 

Such conditions, this crowding effect occurs as well in cancers that are biologically also ranked among the human degenerative diseases. Nonetheless, affected cells, depending on their current replicative potential, can evade such chaos and subsequent cell degeneration by triggering an irreversible functional transition for a beneficial and specific purpose that consists in recycling all their accumulated micro-residues before a subtle death. Except that such immune-like cellular adventure usually faces the amyloidogenic transformation of accumulated unrecycled micro-residues to insoluble, unrecyclable deposits.  .....More


Examples of human ecodiseases:

-       All Benign and Malignant tumors.      -    Multiple sclerosis.

-       Diabetes mellitus type II.            -    Chronic traumatic encephalopathy.

-       Parkinson’s disease.                                   -    Prion diseases.

-       Alzheimer’s disease.                                  -    Cardiovascular diseases.

-       Macular degeneration.                                     -    Multiple system atrophy.

-       Amyotrophic lateral sclerosis.             -   Amyloidosis.      

-       Atherosclerosis.                 -   Immunosenescence......etc.


Some illustrative examples of the origins and causes of unrecycled micro-residues accumulations in humans.  (in French / en Français):   Click here /// Clickez ici