It can be considered as an ecodisease, any disorder of structure or
function in humans, animals or plants, caused by accumulations of unrecycled micro-residues in the organism. Such
aggregations may have endogenous origins and causes, or they can be related to
environmental sources and factors; or both.
In Humans, biologically seen, all known chronic diseases can be
viewed as ecodiseases. However, the proposed restriction aims to
draw attention to the forgotten biological phenomenon of untreated
micro-residues amassing in living organisms, its causes, and its serious
Untreated micro-residues are generally composed of proteins. But they may additionally contain other components such as fatty acids, minerals, etc.
In humans, the origins and causes of unrecycled
micro-residues accumulations can be traced back to:
· Long-time human exposure to harmful environmental agents (Viruses, Bacteria, Radiations, Pesticides, Additives, Alcohol, Drugs, Tobacco, etc.) engenders, first and above all, permanent damage to cells, to their components, and to other cell tissue structures. The result of such persistent injuries is an incessant generation of micro-residues that must be removed, degraded, and recycled.
· Unrecycled micro-residues can also have direct exogenous sources consisting of ingested, applied, or inhaled molecules that the human body cannot use, excrete or recycle, simply because of the lack of competent enzymes.
· Acquired or inherited genetic alterations are
1- A permanent generation of aberrant and, most of the time, inactive proteins which destination cannot be other than the recycling procedure.
2- Gene overexpression, amplification, hyperactivity, or unregulated activity generally result in an incessant production of proteins and are most often materialized by a useless surplus of products that tend to accumulate if not recycled.3- ......
Gaining insight into the pathological processes:
The phenomenon of cell-degeneration, characteristic of various human diseases, arises on a pathological background of unrecycled micro-residues accumulations. Such deposits physically disrupt tissue architecture and activity. They can disturb the cytoskeletal network and vesicular trafficking, and also cause damage to vital cell organelles, etc.
Such conditions, this crowding effect, occur in cancers as well. And that explains why tumors are biologically ranked among human degenerative diseases. Nonetheless, affected cells, depending on their current replicative potential, can evade such chaos and subsequent cell degeneration by triggering an irreversible functional conversion for a beneficial and specific purpose which consists of recycling all their accumulated micro-residues before a subtle death. Except that such immune-like cellular adventure usually faces, in addition to the continuous influx of micro-residues, the amyloidogenic transformation of accumulated unrecycled micro-residues to insoluble, unrecyclable deposits. .....More
Examples of human ecodiseases:
- All Benign and Malignant tumors. - Amyloidosis .
- Diabetes mellitus type II. - Chronic traumatic encephalopathy.
- Parkinson’s disease. - Prion diseases.
- Alzheimer’s disease. - Cardiovascular diseases.
- Macular degeneration. - Multiple system atrophy.
- Amyotrophic lateral sclerosis. - Early Immunosenescence .
Atherosclerosis. - ......etc.